Summary of Topics for Bioengineering/Physiology 6000
System Physiology I
Mid Term #2, 2009 Edition, April 10

Rob MacLeod (macleod@cvrti.utah.edu)

• Forward
• 1 Electrophysiology
  • 1.1 Myocardial Tissue
  • 1.2 Whole heart
  
  
• 2 The circulatory system
• 3 Hemodynamics
• About this document ...

Forward

The following is a list of topics that we covered in the middle part of the semester in Bioengineering 6000 course. I expect students to be familiar with each of the concepts and ideas and will draw from this list for midterm questions.

1 Electrophysiology

1.1 Myocardial Tissue

1. Structural characteristics of myocardial tissue: organization, fibers, gap junctions, syncytium
2. Nature and role of anisotropy
3. Propagation of excitation through myocardial tissue
4. Cell to cell coupling, local circuit currents
5. Gap junction structure, function

1.2 Whole heart

1. Electrophysiology of the whole heart:
   • Structure, role of conduction system,
   • Role of different pacemakers (overdrive suppression),
   • Effects of autonomic nervous system on the heart,
   • Activation sequence of the heart,
   • Defibrillation mechanisms.
2. Electrocardiography
   • Basic physiology and biophysics of the ECG, components required for ECG to arise,
   • Heart dipole and the sequence of activation,
   • Lead systems,
   • Interpretation of ECGs.

2 The circulatory system

1. Roles and functions of the circulatory system.
2. Open versus closed cardiovascular systems.
3. Role of blood.
4. Control of red blood cell production.
5. Injury, clotting, and coagulation.

3 Hemodynamics

1. Limitations of applying classical hemodynamics to blood.
2. Hemodynamic parameters and what they mean.
3. Effects and mechanisms of stenosis on blood flow and pressure,
4. Poiseuille's Law, resistance, and viscosity of blood.
5. Area-resistance paradox in the resistance vessels (arterioles) of the arterial system.

About this document ...

Summary of Topics for Bioengineering/Physiology 6000
System Physiology I
Mid Term #2, 2009 Edition, April 10

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