Research Assistant Professor, Department of Internal Medicine (Division of Cardiology)
Research Assistant Professor Department of Bioengineering
B.S., Mechanical Engineering, University of Arizona, Tucson, AZ
M.S., Mechanical Engineering, University of Arizona, Tucson, AZ
Ph.D., Biomedical Engineering, University of North Carolina, Chapel Hill, NC
The primary focus of my research is to investigate the lethal link between diabetes and cardiovascular disease.
Working with genetically modified mouse models associated with diabetes, my lab is applying voltage-sensitive optical imaging, conventional electrical imaging, tissue resistivity measures and measures of calcium and potassium ions to phenotype electrophysiologic changes associated with some specific aspects of diabetes, namely insulin resistance and the down regulation of glucose transport.
My lab is also studying the effects of glucose levels and insulin signaling on the electrical activity during hypoxic and ischemic conditions in Langendorff perfused isolated mouse hearts in order to characterize the direct relationship between electrical activity and glucose and insulin availability.
Please visit my lab's web page for more information.
Taccardi B, Punske BB, Macchi E, Macleod RS, Ershler PR:Epicardial and Intramural Excitation During Ventricular Pacing: Effect of Myocardial Structure.Am J Physiol Heart Circ Physiol, 2008
Shome S, Lux RL, Punske BB, MacLeod RS:Ischemic preconditioning protects against arrhythmogenesis through maintenance of both active as well as passive electrical properties in ischemic canine hearts.J Electrocardiol,40,S150-9,2007
Shome S, Lux RL, Punske BB, MacLeod RS:Ischemic Preconditioning Protects Against Arrhythmogenesis Through Maintenance of Both Active as well as Passive Electrical Properties.J Electrocardiol, 2007
Sohn K, Sutherland DR, Liang Q, Punske BB:Experimental Measures of the Minimum Time Derivative of the Extracellular Potentials as an Index of Electrical Activity During Metabolic and Hypoxic Stress.Functional Imaging and Modeling of the Heart,4466,250-259,2007
Sutherland DR, Liang Q, Sohn K, Taccardi B, Punske BB: Experimental Epicaridal Potential Mapping in Mouse Ventricles: Effect of Fiber Architecture.Functional Imaging and Modeling of the Heart,4466,260-268,2007
DR Sutherland, J Adams, BB Punske: Methods for Accurate Measures of Total Ventricular Activation Time.28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society,3947-3949,2006
Valencik ML, Zhang D, Punske B, Hu P, McDonald JA, Litwin SE:Integrin activation in the heart: a link between electrical and contractile dysfunction?.Circ Res,99,1403-10,2006
Sutherland DR, Adams J, Punske BB: Methods for accurate measures of total ventricular activation time.Conf Proc IEEE Eng Med Biol Soc,1,3947-9,2006
Liang Q, Sohn K, Punske BB:Propagation and electrical impedance changes due to ischemia, hypoxia and reperfusion in mouse hearts.Conf Proc IEEE Eng Med Biol Soc,1,1560-3,2006
Q. Lian, K. Sohn, BB Punske: Propagation and Electrical Impedance Changes due to Ischemia, Hypoxia and Reperfusion in Mouse Hearts.28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society,1560-1563,2006
Punske BB: Cardiac resynchronization therapy: finding the true meaning of synchrony.Heart Rhythm,3,311-2,2006
Yilmaz B, MacLeod RS, Punske BB, Taccardi B, Brooks DH:Venous catheter based mapping of ectopic epicardial activation: training data set selection for statistical estimation.IEEE Trans Biomed Eng,52,1823-31,2005
Taccardi B, Punske BB, Sachse F, Tricoche X, Colli-Franzone P, Pavarino LF, Zabawa C:Intramural activation and repolarization sequences in canine ventricles. Experimental and simulation studies.J Electrocardiol,38,131-7,2005
Punske BB, Taccardi B, Steadman B, Ershler PR, England A, Valencik ML, McDonald JA, Litwin SE:Effect of fiber orientation on propagation: electrical mapping of genetically altered mouse hearts.J Electrocardiol,38,40-4,2005
MacLeod RS, Shome S, Stinstra J, Punske BB, Hopenfeld B:Mechanisms of ischemia-induced ST-segment changes.J Electrocardiol,38,8-13,2005
F. B. Sachse, G. Seemann, D. L. Weifl, B. Punske, and B. Taccardi:Accuracy of activation times detected in simulated extracellular electrograms.Computers in Cardiology,31,93-96,2004
F. B. Sachse, B. W. Steadman, J. H. B. Bridge, B.B. Punske, and B. Taccardi:Conduction velocity in myocardium modulated by strain: Measurement instrumentation and initial results.26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society,2004
B. Taccardi, B.B. Punske, and P. Colli Franzone: Cardiac Potential Mapping.The 26th International Conference of the IEEE Engineering in Medicine and Biology Society,3593-3596,2004