Professor of Medicine
B.S. in Biology. National School of Biological Sciences, IPN. Mexico.
Ph.D. in Physiology and Biophysics, Centro de Investigacion y Estudios Avanzados (CINVESTAV) IPN, Mexico. Department of Physiology, Biophysics and Neuroscience.
Molecular and biophysical properties of gap junctions.
Moreno AP, Berthoud VM, Perez-Palacios G, Perez-Armendariz EM. Biophysical evidence that connexin 36 forms functional gap junction channels between pancreatic mouse {beta}-cells. Am J Physiol Endocrinol Metab. 2004 Dec 29; [Epub ahead of print]
Moreno AP. Biophysical properties of homomeric and heteromultimeric channels formed by cardiac connexins. Cardiovasc Res. 2004 May 1;62(2):276-86. Review.
Zhong G., Matel, P., Jiang X., Jarry-Guichard T., Gros, D., Labarrere, C., and A.P. Moreno. (2003) LacSwitch II-regulation of Cx43 cDNA expression enables gap junction single channel analysis. Biotechniques 34:1034-1046.
Martinez AD, Hayrapetyan V, Moreno AP, Beyer EC. A carboxyl terminal domain of connexin43 is critical for gap junction plaque formation but not for homo- or hetero-oligomerization. Cell Commun Adhes. 2003 10(4-6):323-8.
Zhong G, Mantel PL, Jiang X, Jarry-Guichard T, Gros D, Labarrere C, Moreno AP. LacSwitch II regulation of connexin43 cDNA expression enables gap-junction single-channel analysis. Biotechniques. 2003 ;34(5):1034-9, 1041-4, 1046.
Moreno A.P. Chanson, Elenes S., M, Anumonwo, J.M.B., Taffet, S.M. and M. Delmar (2002). Role of the Carboxyl terminal of Cx43 as an effector of transjunctional fast voltage gating. Circ. Res. 90:450-457.
Moreno AP. Filling more gaps: consequences of heterogeneous remodeling in connexin expression. J Cardiovasc Electrophysiol. 2002;13(9):871-2.
Martinez, A.D., Hayrapetian, V., A. P. Moreno, Beyer E.C. (2002) Connexin43 and Connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation. Circ. Res. 90:1100-1107.
Goldberg S.G., Moreno A.P. and Lampe P.D. (2002) Gap junctions between cells expressing Cx43 or 32 show inverse perm-selectivity to adenosine and ATP J. Biol. Chem. 277; 36725-36730.
Anumonwo J., Taffet S.M., Gu H., Chanson M., Moreno A.P., and M. Delmar. (2001) The Carboxyl Terminal Domain Regulates the Unitary Conductance and Voltage Dependence of Connexin40 Gap Junction Channels Circ. Res. 2001 88(7): p. 666-673
Elenes S. Martinez, A., Beyer E.C. and A.P. Moreno.(2001) Heterotypic docking of Cx43 and Cx45 connexons blocks the fast gating of Cx43. Biophys. J. 81: 1406-1418.
Chen-Izu, Y., A.P. Moreno and R. A. Spangler (2001). Opposing gates model for voltage gating of gap junction channels. Am.J. Physiol. 281: C1604-C1613.
Heteromeric mixing of connexins: compatibility of partners and functional consequences (2001). Beyer E.C., Gemel H., A. Martinez A., Berthoud, V.M., Valiunas V., Moreno A.P. and Brink P.R. Cell communication and adhesion, 8 (4-6);1-6
Elenes S., Rubart M. and A. P. Moreno. (1999) Junctional communication between isolated pairs of canine atrial cells is mediated by homogeneous and heterogeneous gap junction channels. J. Cardiovasc. Electrophysiol. 10;990-1004.