Faculty

Dipl.-Inform., Universitaet Karlsruhe, Germany

Dr.-Ing., Universitaet Karlsruhe, Germany

PD, Universitaet Karlsruhe, Germany

Cardiac Electro-Mechanics; Biophysical Modeling of Ion Channels, Cells and Tissue; Confocal Imaging

Fernandez D, Sargent J, Sachse FB, Sanguinetti MC. Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid. Mol Pharmacol. 2008 Apr;73(4):1159-67. Epub 2008 Jan 24.

Rodríguez-Menchaca AA, Navarro-Polanco RA, Ferrer-Villada T, Rupp J, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA. The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1364-8. Epub 2008 Jan 23.

D. R. Piper, J. Rupp, F. B. Sachse, M. C. Sanguinetti, and M. Tristani-Firouzi. Cooperative interactions between R531 and basic residues in the voltage sensing module of hERG1 channels. Cell Physiol Biochem, 21:37-46, 2008.

F. B. Sachse, E. Savio-Galimberti, J. I. Goldhaber, and J. H. B. Bridge. Sub-micrometer anatomical models of the sarcolemma of cardiac myocytes based on confocal imaging. In Proc. Pacific Symposium on Biocomputing, volume 13, pages 390-401, 2008.

F. B. Sachse, A. P. Moreno, and J. A. Abildskov. Electrophysiological modeling of fibroblasts and their interaction with myocytes. Ann Biomed Eng, 36(1):41-56, 2008.

M. D. Perry, F. B. Sachse, and M. C. Sanguinetti. Structural basis of action for a human ether-a-go-go related gene 1 potassium channel activator. Proc Natl Acad Sci U S A, 104(34):13827-32, 2007.

S. E. Geneser, R. M. Kirby, D. Xiu, and F. B. Sachse. Stochastic markovian modeling of electrophysiology of ion channels: Reconstruction of standard deviations in macroscopic currents. J Theor Biol, 245(4):627-637, 2007. EPub 2006 Oct 20.

C. Putzke, K. Wemhoener, F. B. Sachse, S. Rinne, G. Schlichthoerl, X. T. Lia, L. Jae, I. Eckhardt, E. Wischmeyer, H. Wulf, R. Preisig-Mueller, J. Daut, and N. Decher. The acid-sensitive potassium channel TASK-1 in rat cardiac muscle. Cardiovasc Res, 75(1):59-68, 2007. EPub 2007 Feb 28.

F. B. Sachse and G. Seemann, editors. Functional Imaging and Modeling of the Heart, volume 4466 of Lecture Notes in Computer Science. Springer, 2007.

E. Savio, J. I. Goldhaber, J. H. B. Bridge, and F. B. Sachse. A framework for analyzing confocal images of transversal tubules in cardiomyocytes. In F. B. Sachse and G. Seemann, editors, Lecture Notes in Computer Science, volume 4466, pages 110-119, 2007.

G. Seemann, F. B. Sachse, D. L Weiss, L. J. Ptacek, and M. Tristani-Firouzi. Modeling of IK1 mutations in human left ventricular myocytes and tissue. Am J Physiol Heart Circ Physiol, 292(1):H549-59, 2007

G. Seemann, C. Hoeper, F. B. Sachse, O. Doessel, A. V. Holden, and H. Zhang. Heterogeneous three-dimensional anatomical and electrophysiological model of human atria. Phil. Trans. Roy. Soc. A, 364:1465-1481, Apr. 2006.

E. Hughes, B. Taccardi, and F. B. Sachse. A heuristic streamline placement technique for visualization of electrical current flow. J Flow Visualization and Image Processing, 13(1):53-66, 2006.

I. Splawski, K. W. Timothy, N. Decher, P. Kumar, F. B. Sachse, A. H. Beggs, M. C. Sanguinetti, and M. T. Keating. Severe arrhythmia disorder caused by cardiac l-type calcium channel mutations. Proc Natl Acad Sci U S A, 102(23):8089-8096, June 2005.

K. Hong, D. R. Piper, A. Diaz-Valdecantos, J. Brugada, E. Burashnikov, J. Santos de Soto, J. Grueso-Montero, P. Brugada, F. B. Sachse, M. C. Sanguinetti, and R. Brugada. De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero. Cardiovas. Res., 68(3):433-440, 2005.

B. Taccardi, B. B. Punske, F. Sachse, X. Tricoche, P. Colli-Franzone, L. Pavarino, and C. Zabawa. Intramural activation and repolarization sequences in canine ventricles. experimental and simulation studies. J Electrocardiol, 38S4:131-137, 2005.

D. L. Weiss, G. Seemann, F. B. Sachse, and O. Dössel. Modeling of the short QT syndrome in a heterogeneous model of the human ventricular wall. Europace, 7S2:105-117, 2005.

F. B. Sachse. Computational Cardiology: Modeling of Anatomy, Electrophysiology, and Mechanics. LNCS 2966. Springer, Berlin, Heidelberg, New York, 2004.

M. B. Mohr, L. G. Blümcke, Seemann, F. B. Sachse, and O. Dössel. Volume modeling of myocard deformation using a spring mass system. LNCS 2673, pages 332-339, 2003.

F. B. Sachse and G. Seemann. Modeling of cardiac electro-mechanics in a truncated ellipsoid model of left ventricle. LNCS 2673, pages 253-260, 2003.

F. B. Sachse, K. Glänzel, and G. Seemann. Modeling of electro-mechanical coupling in cardiac myocytes: Feedback mechanisms and cooperativity. LNCS 2674, pages 62-71, 2003.

F. B. Sachse, K. Glänzel, and G. Seemann. Modeling of protein interactions involved in cardiac tension development. Int. J. Bifurc. Chaos, 13(12):3561-3578, 2003.

G. Seemann, F. B. Sachse, D. L. Weiß, and O. Dössel. Quantitative reconstruction of cardiac electromechanics in human myocardium: Regional heterogeneity. J. Cardiovasc. Electrophysiol., 14(S10):S219-S228, Oct. 2003

F. B. Sachse, C. D. Werner, and G. Seemann. Simulation of cardiac electrophysiology and electrocardiography. In N. Virag, O. Blanc, and L. Kappenberger, editors, Computer Simulation and Experimental Assessment of Cardiac Electrophysiology, pages 97-104. Futura Publishing, Armonk, New York, 2001.

F. B. Sachse, G. Seemann, and C. D. Werner. Combining the electrical and mechanical functions of the heart. Int. J. Bioelectromagnetism, 3(2), 2001

F. B. Sachse, C. D. Werner, K. Meyer-Waarden, and O. Dössel. Development of a human body model for numerical calculation of electrical fields. Computerized Medical Imaging and Graphics, 24:165-171, 2000.