Inventors at the CVRTI (Drs. Sachse and Bridge) and the Bioengineering Department (Dr. Hitchcock) developed an approach for local delivery of fluorescent dyes, which simplifies imaging of tissue micro-structure using fiber-optics confocal microscopy. The approach has applications in basic medical research and clinical diagnosis of diseases. An international patent application (WO 2010/016885 A1) was published on the 11. Feb. 2010.