B.S. 1976, Humboldt State University
M.S. 1978, San Jose State University
PhD. 1982, University of California, Davis Postdoctoral Fellow, University of Rochester

My laboratory is interested in the ionic basis of cardiac repolarization and the structural basis of ion channel function. Cardiac repolarization is dependent on activation of a surprisingly large number of potassium channels. Mutations in the genes encoding many of these channels cause inherited forms of cardiac arrhythmia. We use site-directed mutagenesis of cloned channels and voltage clamp techniques to study the molecular basis of potassium channel dysfunction in these human disorders. In addition, we are exploring the molecular mechanisms that cause delayed rectifier and pacemaker channels to open and close in response to changes in transmembrane voltage.

Cheng L, Sanguinetti MC. Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains. Mol Pharmacol. 2009

Brown S, Sonntag DP, Sanguinetti MC. A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating. Cell Physiol Biochem. 2008;22(5-6):601-610

Decher N, Gonzalez T, Sachse FB, Renigunta V, Streit AK, Soom M, Heineman SH, Daut J, Sanguinetti M. Structural determinants of Kv?1.3 induced channel inactivation: a hairpin modulated by PIP2. EMBO J. 2008;27(23):3164-3174

Fernandez D, Sargent JD, Sachse FB, Sanguinetti M. Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid. Mol Pharmacol. 2008;73(4):1159-1167

Kimiya K, Niwa R, Morishima M, Honjo H, Sanguinetti M. Molecular determinants of hERG channel clock by erfenadine and cisapride. J Pharmacol Sci. 2008;108(3):301-307

Perry M, Sanguinetti MC. A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator. Mol Pharmacol. 2008;73(4):1044-1051

Piper DR, Rupp J, Sachse FB, Sanguinetti MC, Tristani-Firouzi M. Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels. Cell Physiol Biochem. 2008;21(1-3):37-46

Restier L, Cheng L, Sanguinetti M. Mechanisms by which atrial fibrillation-associaed muttions in the S1 domain of KCNQ1 slow deactivation of Iks channels. J Physiol. 2008;586:4179-4191

Rosati B, Dong M, Cheng L, Liou SR, Yan Q, Park JY, Shiang E, Sanguinetti M, Wang H, McKinnon D. Evolution of ventricular myocyte electrophysiology. Physiological Genomics. 2008;35:262-272

Seebohm G, Strutz-Seebohm N, Ureche O, Henrion U, Baltaev R, Mack AF, Kornichuk G, Pfeufer A, Bucci C, Pagano RE, Attali B, Merot J, Tavare JM, Sanguinetti M, Lang F. Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of Iks channels. Circ Res. 2008;103(12):1451-1457