Faculty
Michael F. Sheets, MD
Professor of Internal MedicineAssociate Director, Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah
University of Utah, CVRTI
95 South 2000 East
Salt Lake City, Utah 84112-5000, USA
Email: contact
Phone: (801) 585-3320
Fax: (801) 581-3128
Education
B.S. University of Wisconsin, Madison
M.D. University of Iowa, Iowa City, IA
M.D. University of Iowa, Iowa City, IA
Interests
Cardiac electrophysiology and voltage-gated ion channels.
Collaborations
Dr. Dorothy Hanck, University of Chicago
Selected
Publications
| Fozzard HA, Sheets MF, Hanck DA. The Sodium Channel as a Target for Local Anesthetic Drugs. Front Pharmacology. 2011;2:1-6 online |
| Sheets MF, Chen T, Hanck DA. Lidocaine Partially Depolarizes the S4 Segment in Domain IV of the Sodium Channel. European Journal of Physiology. 2011;461:91-97 online |
| Barry WH, Zhang XQ, Halkos ME, Vinten-Johansen J, Saegusa N, Spitzer KW, Matsuoka N, Sheets M, Rao NV, Kennedy T. Non-Anticoagulant Heparin Reduces Myocyte Na+ and Ca2+ Loading During Simulated Ischemia and Decreases Reperfusion Injury. Am. J. Physiol.. 2010;298:H102-H111 online |
| French RJ, Yoshikami D, Sheets MF, Olivera BM. The Tetrodotoxin Receptor of Voltage-Gated Sodium Channels—Perspectives from Interactions with µ-Conotoxins. Mar. Drugs. 2010;8:2153-2161 online |
| Sheets MF, Fozzard HA, Lipkind GM, Hanck DA. Sodium Channel Molecular Conformations and Antiarrhythmic Drug Affinity. Trends. Cardiovasc. Med.. 2010;20:16-21 online |
| Hanck DA, Nikitina E, McNulty MM, Fozzard HA, Sheets MF. Using Lidocaine and Benzocaine to Link Sodium Channel Molecular Conformations to State-Dependent Antiarrhythmic Drug Affinity. Circ. Res. 2009;105:492-499 online |
| Sheets MF, Hanck DA. Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels. J Physiol. 2007;582((Pt 1)):317-334 |
| Chen T, Inoue M, Sheets MF. Reduced voltage dependence of inactivation in the SCN5A sodium channel mutation delF1617. Am J Physiol Heart Circ Physiol. 2005;288(6):H2666-2676 |
| Sheets MF, Hanck DA. Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation. J Physiol. 2005;563(Pt. 1):83-93 online |
| Su Z, Sheets MF, Ishida H, Li F, Barry WH. Saxitoxin blocks L-type ICa. J Pharmacol Exp Ther. 2004;308(1):324-329 |