M.Sc. The Danish University of Pharmaceutical Sciences, Denmark 2006
Ph.D. The University of Copenhagen, Denmark 2009

Role of dynamic heterogeneities in cardiac arrhythmogenesis
Cardiac voltage-gated potassium channels
Electrophysiological effects of diabetic cardiomyopathy


Publications (PubMed)

Olesen MS, Refsgaard L, Holst AG, Larsen AP, Grubb S, Haunsø S, Svendsen JH, Olesen SP, Schmitt N, Calloe K. A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation. Cardiovasc Res. 2013 Feb 11. Epub ahead of print. (Abstract)

Christophersen IE, Olesen MS, Liang B, Andersen MN, Larsen AP, Nielsen JB, Haunsø S, Olesen SP, Tveit A, Svendsen JH, Schmitt N. Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation. Eur Heart J. 2012 Dec 21. Epub ahead of print. (Abstract)

Veeraraghavan R, Larsen AP, Torres NS, Grunnet M, Poelzing S. Potassium channel activators differentially modulate the effect of sodium channel blockade on cardiac conduction. Acta Physiol (Oxf). 2013; 207(2):280-9. (Abstract)

Larsen AP, Sciuto KJ, Moreno AP, Poelzing S. The voltage-sensitive dye di-4-ANEPPS slows conduction velocity in isolated guinea pig hearts. Heart Rhythm. 2012; 9(9):1493-500. (Abstract)

Larsen AP, Steffensen AB, Grunnet M, Olesen SP. Extracellular Potassium Inhibits Kv7.1 Potassium Channels by Stabilizing an Inactivated State. Biophys J. 2011; 101(4):818-27. (Abstract)

Bentzen BH, Bahrke S, Wu K, Larsen AP, Odening KE, Franke G, van´s Gravesande KS, Biermann J, Peng X, Koren G, Zehender M, Bode C, Grunnet M, Brunner M. Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits. J Cardiovasc Pharmacol. 2011; 57(2):223-30. (Abstract)

Larsen AP. Role of ERG1 isoforms in modulation of ERG1 channel trafficking and function. Pflugers Arch. 2010; 460(5):803-12. (Abstract)

Larsen AP, Bentzen BH, Grunnet M. Differential effects of K_v11.1 activators on K_v11.1a, K_v11.1b and K_v11.1a/K_v11.1b channels. Br J Pharmacol. 2010; 161(3):614-28. (Abstract)

Larsen AP, Olesen SP, Grunnet M, Poelzing S. Pharmacological activation of IKr impairs conduction in guinea pig hearts. J Cardiovasc Electrophysiol. 2010; 21(8):923-9. (Abstract | Editorial comment)

Larsen AP, Olesen SP. Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics. PLoS One. 2010; 5(2):e9021. (Abstract)

Osadchii OE, Larsen AP, Olesen SP. Predictive value of electrical restitution in hypokalemia-induced ventricular arrhythmogenicity. Am J Physiol Heart Circ Physiol. 2010; 298(1):H210-20. (Abstract)

Larsen AP, Olesen SP, Grunnet M, Jespersen T. Characterization of hERG1a and hERG1b potassium channels - a possible role for hERG1b in the I(Kr) current. Pflugers Arch. 2008; 456(6):1137-48. (Abstract)

Parmeggiani F, Pellarin R, Larsen AP, Varadamsetty G, Stumpp MT, Zerbe O, Caflisch A, Plückthun A. Designed armadillo repeat proteins as general peptide-binding scaffolds: consensus design and computational optimization of the hydrophobic core. J Mol Biol. 2008; 376(5):1282-304. (Abstract)


Patents / patent applications

Parmeggiani F, Pellarin R, Larsen AP, Varadamsetty G, Stumpp MT and Plückthun A. Designed Armadillo Repeat Proteins (Publication number: WO/2009/040338)


Teaching

Classes
Bioen 6464 - Cardiac Electrophysiology and Biophysics Seminar (Spring 2012, 2013)
Bioen 6003 - Cellular Electrophysiology and Biophysics (Fall 2012)

Academic advisor - Graduate research projects
Rikke M Pedersen, Master's thesis research, Feb-Nov 2012 (Universities of Utah and Copenhagen)

Danish Council for Independent Research, post-doctoral grant (2012-2014)
Carlsberg Foundation, post-doctoral scholarship (2010-2012)
Faculty of Health Sciences, University of Copenhagen, post-doctoral grant (2009)
Danish Arrhythmia Research Centre, pre-doctoral scholarship (2006-2009)

The Ion Channel Lab at the University of Copenhagen (ionchannel.ku.dk)
Danish Arrhythmia Research Center (darc.ku.dk)