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Sachse FB, Seemann G. Special issue: Functional imaging and modelling of the heart. Med Image Anal. 2009;13(2):345
Sachse FB, Savio-Galimberti E, Goldhaber JI, Bridge JH. Towards computational modeling of excitation-contraction coupling in cardiac myocytes: reconstruction of structures and proteins from confocal imaging. Pac Symp Biocomput. 2009:328-339
Sachse FB, Moreno AP, Seemann G, Abildskov JA. A model of electrical conduction in cardiac tissue including fibroblasts. Ann Biomed Eng. 2009;37(5):874-889
Oakes RS, Badger TJ, Kholmovski EG, Akoum N, Burgon NS, Fish EN, Blauer JJ, Rao SN, DiBella EV, Segerson NM, Daccarett M, Windfelder J, McGann CJ, Parker D, MacLeod RS, Marrouche NF. Detection and quantification of left atrial structural remodeling with delayed-enhancement magnetic resonance imaging in patients with atrial fibrillation. Circulation. 2009;119(13):1758-1767
Hamdan MH, . Hemodynamic monitoring during syncope: utility and limitations. J Cardiovasc Electrophysiol. 2009;20(1):82-84
Cheng L, Sanguinetti MC. Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains. Mol Pharmacol. 2009
Badger TJ, Oakes RS, Daccarett M, Burgon NS, Akoum N, Fish EN, Blauer JJ, Rao SN, Adjei-Poku Y, Kholmovski EG, Vijayakumar S, Di Bella EV, MacLeod RS, Marrouche NF. Temporal left atrial lesion formation after ablation of atrial fibrillation. Heart Rhythm. 2009;6(2):161-168
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Sobie EA, Cannell MB, Bridge JH. Allosteric activation of Na+-Ca+ exchange by L-typ[e Ca2+ curent augments the trigger flux for SR Ca2+ release in ventricular myocytes. Biophys J. 2008:L54-L56 online
Seebohm G, Strutz-Seebohm N, Ureche O, Henrion U, Baltaev R, Mack AF, Kornichuk G, Pfeufer A, Bucci C, Pagano RE, Attali B, Merot J, Tavare JM, Sanguinetti M, Lang F. Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of Iks channels. Circ Res. 2008;103(12):1451-1457
Savio-Galimberti E, Frank J, Inoue M, Goldhaber JI, Cannell MB, Bridge JH, Sachse FB. Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images. Biophys J. 2008;95(4):2053-2062
Sandhu RK, Costantini O, Cummings JE, Poelzing S, Rosenbaum DS, Quan KJ. Intracardiac alternans compared to surface T-wave alternans as a predictor of ventricular arrhythmias in humans. Heart Rhythm. 2008;5(7):1003-1008
Sachse FB, Savio-Galimberti E, Goldhaber JI, Bridge JH. Sub-micrometer anatomical models of the sarcolemma of cardiac myocytes based on confocal imaging. Pac Symp Biocomput. 2008:390-401
Rosati B, Dong M, Cheng L, Liou SR, Yan Q, Park JY, Shiang E, Sanguinetti M, Wang H, McKinnon D. Evolution of ventricular myocyte electrophysiology. Physiological Genomics. 2008;35:262-272
Rodriguez-Menchaca AA, Navarro-Polanco RA, Ferrer-Villada T, Rupp J, Sachse FB, Tristani-Firouzi M, Sanchez-Chapula JA. The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc Natl Acad Sci U S A. 2008;105(4):1364-1368
Restier L, Cheng L, Sanguinetti M. Mechanisms by which atrial fibrillation-associaed muttions in the S1 domain of KCNQ1 slow deactivation of Iks channels. J Physiol. 2008;586:4179-4191
Poelzing S, Smoot AF, Veeraraghavan R. Novel x-ray attenuation mechanism: role of interatomic distance. Med Phys. 2008;35(10):4386-4395
Piper DR, Rupp J, Sachse FB, Sanguinetti MC, Tristani-Firouzi M. Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels. Cell Physiol Biochem. 2008;21(1-3):37-46
Perry M, Sanguinetti MC. A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator. Mol Pharmacol. 2008;73(4):1044-1051
Pellizzon OA, Kalaizich L, Ptacek LJ, Tristani-Firouzi M, Gonzalez MD. Flecainide suppresses bidirectional ventricular tachycardia and reverses tachycardia-induced cardiomyopathy in Andersen-Tawil syndrome. J Cardiovasc Electrophysiol. 2008;19(1):95-97
McNary TG, Sohn K, Taccardi B, Sachse FB. Experimental and computational studies of strain-conduction velocity relationships in cardiac tissue. Prog Biophys & Mol Biol. 2008;97(2):383-400
Kimiya K, Niwa R, Morishima M, Honjo H, Sanguinetti M. Molecular determinants of hERG channel clock by erfenadine and cisapride. J Pharmacol Sci. 2008;108(3):301-307
Fernandez D, Sargent JD, Sachse FB, Sanguinetti M. Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid. Mol Pharmacol. 2008;73(4):1159-1167
Decher N, Gonzalez T, Sachse FB, Renigunta V, Streit AK, Soom M, Heineman SH, Daut J, Sanguinetti M. Structural determinants of Kv?1.3 induced channel inactivation: a hairpin modulated by PIP2. EMBO J. 2008;27(23):3164-3174
Chantawansri C, Huynh N, Yamanaka J, Garfinkel A, Lamp ST, Inoue M, Bridge JH, Goldhaber JI. Effect of metabolic inhibition on couplon behavior in rabbit ventricular myocytes. Biophys J. 2008;94(5):1656-1666
Brown S, Sonntag DP, Sanguinetti MC. A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating. Cell Physiol Biochem. 2008;22(5-6):601-610
Bridge JH, Savio-Galimberti E. What are the consequences of phosphorylation and hyperphosphorylation of ryanodine receptors in normal and failing heart?. Circ Res. 2008;102(9):995-997
Yamamoto T, Shirayama T, Takahashi T, Tanaka H, Takamatsu T, Spitzer KW, Matsubara H. Enhanced activity of ventricular Na+-HCO3-cotransport in pressure-overload hypertrophy. Am J Physiol. 2007;293(2):H1254-H1264 online
Weiss D, Seemann G, Keller DUJ, Farina D, Sachse FB. Modeling of heterogeneous electrophysiology in the human heart with respect to ECG genesis. Paper presented at:CiC, 2007
Warren MD, Huizar JF, Shvedko AG, Zaitsev AV. Spatiotemporal relationship between intracellular Ca2+ dynamics and wave fragmentation during ventricular fibrillation in isolated blood-perfused pig hearts. Circ Res. 2007;101:e90-e101 online
Tanaka K, Zlochiver S, Vikstrom K, Yamazaki M, Moreno J, Klos M, Zaitsev AV, Vaidyanathan R, Aluerbach DS, Landas S, Guiraudon G, Jalife J, Berenfeld O, Kalifa J. The spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure. Circ Res. 2007;101:837-847 online
Swietach P, Spitzer KW, Vaughan-Jones RD. pH-dependence of extrinsic and intrinsic H(+)-ion mobility in the rat ventricular myocyte, investigated using flash photolysis of a caged-H(+) compound. Biophys J. 2007;92(2):641-653 online
Swietach P, Rossini A, Spitzer KW, Vaughan-Jones RD. H+ ion activation and inactivation of the ventricular gap junction: a basis for spatial regulation of intracellular pH. Circ Res. 2007;100(7):1045-1054 online
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Sohn K, Sutherland DR, Liang Q, Punske B. Experimental measures of the minimum time derivative of the extracellular potentials as an index of electrical activity during metabolic and hypoxic stress. Functional Imaging and Modeling of the Heart;2007:250-259.
Shome S, Lux RL, Punske B, MacLeod R. Ischemic preconditioning protects against arrhythmogenesis throughout maintenance of both active as well as passive electrical properties in ischemic canine hearts. J Electrocardiol. 2007;40(Supplement):In press online
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Sheets MF, Hanck DA. Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels. J Physiol. 2007;582((Pt 1)):317-334 online
Segerson NM, Wasmund SL, Abedin M, Pai RK, Daccarett M, Akoum N, Wall TS, Klein RC, Freedman RA, Hamdan MH. Heart rate turbulence parameters correlate with post-premature ventricular contraction changes in muscle sympathetic activity. Heart Rhythm. 2007;4(3):284-289
Segerson NM, Sharma N, Smith ML, Wasmund SL, Kowal RC, Abedin M, Macgregor JF, , Pai RK, Freedman RA, Hamdan MH. The effects of rate and irregularity on sympathetic nerve activity in human subjects. Heart Rhythm. 2007;4(1):20-26 online
Segerson NM, Litwin SE, Daccarett M, Wall TS, Hamdan MH, Lux RL. Scatter in repolarization timing predicts clinical events in post-myocardial infarction patients. Heart Rhythm. 2007:In press
Seemann G, Sachse FB, Weiss DL, Ptacek LJ, Tristani-Firouzi M. Modeling of IK1 mutations in human left ventricular myocytes and tissue. Am J Physiol Heart Circ Physiol. 2007;292(1):H549-559
Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Kornichuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti M, Tavare JM, Lang F. Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels.
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Schindler DM, Lux RL, Shusterman V, Drew BJ. Karhunen-Loeve representation distinguishes ST-T wave morphology differences Between non-ST elevation myocardial infarction and non-acute coronary syndrome patients presenting to the emergency departm. J Electrocardiol. 2007;40(Supplement):In press online
Savio-Galimberti E, Goldhaber JI, Bridge JH, Sachse FB. A framework for analyzing confocal images of transversal tubules in cardiomyocytes. Lecture Notes in Computer Science. Vol 4466. Springer-Verlag;2007:110-119.
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Sachse FB, Hunter AM, Weiss DL, Seeman G. A framework for modeling of mechano-electrical feedback mechanisms of cardiac myocytes and tissues. Paper presented at:IEEE EMBS, 2007
Sachse FB, Moreno AP, Abildskov JA. Electrophysiological modeling of fibroblasts and their interaction with myocytes. Paper presented at:International Gap Junctions , 2007
Putzke C, Wemhoner K, Sachse FB, Rinne S, Schlichthorl G, Lia XT, Jae L, Eckhardt I, Wischmeyer E, Wulf H, Preisig-Muller R, Daut J, Decher N. The acid-sensitive potassium channel TASK-1 in rat cardiac muscle. Cardiovasc Res. 2007;75(1):59-68 online
Poelzing S, Veeraraghaven R. Heterogeneous ventricular chamber response to hypokalemia and inward rectifier potassium channel blockade underlies bifurcated T wave in guinea pig. Am J Physiol Heart Circ Physiol. 2007;292(6):H3043-H3051 online
Peters S, Schulze-Bahr E, Etheridge SP, Tristani-Firouzi M. Sudden cardiac death in Andersen-Tawil syndrome. Europace. 2007;9(3):162-166
Perry M, Sachse FB, Sanguinetti M. Structural basis of action for a human ether-a-go-go-related gene1 potassium channel activator. Proc Natl Acad Sci U S A. 2007;104(13827-13832)
Moreno AP, Lau AF. Gap junction channel gating modulated through protein phosphorylation. Prog Biophys Mol Biol. 2007;94:107-119 online
McNary TG, Sohn K, Taccardi B, Sachse FB. The effects of streptomycin on strain-conduction velocity relationship in rabbit papillary muscle. Paper presented at:3rd Annual Mountain West Biomedical Engineering , 2007
McNary TG, Sohn K, Taccardi B, Sachse FB. The strain-conduction velocity relationship in rabbit papillary muscle. Paper presented at:Cardiac MEF and Arrhythmias, 2007;Oxford
Matiukas A, Mitrea BG, Qin M, Pertsov AM, Shvedko SG, Warren MD, Zaitsev AV, Wuskell JP, Wei M, Watras J, Loew LM. Near infrared voltage sensitive fluorescent dyes optimized for optical mapping in blood-perfused myocardium. Heart Rhythm. 2007;4(11):1441-1451
Huizar JF, Warren MD, Shvedko SG, Kalifa J, Moreno J, Mironov SF, Jalife J, Zaitsev AV. Three distinct phases of VF during global ischemia in the isolated blood-perfused pig heart. Am J Physiol Heart Circ Physiol. 2007;293:H1617-H1628
Hamdan MH, . The Benefits of CRT: Mechanical Remodeling and Beyond! . Pacing Clin Electrophysiol. 2007;30(5):587-590
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Glatter KA, Hamdan MH, Zhang Q, Chiamvimonvat N. Drug-induced long QT syndrome: a continuing challenge in the field. J Cardiovasc Electrophysiol. 2007;18(7):696-697
Geneser SE, Kirby M, Xiu D, Sachse FB. Application of the stochastic galerkin method for analysis of human cardiac ion channel models. Paper presented at:SIAM, 2007
Drew BJ, Schindler DM, Zegre J, Fleischmann KE, Lux RL. Estimated body surface potential maps in emergency department patients with unrecognized unstable angina. J Electrocardiol. 2007;40(Supplement):In press
Decher N, Renigunta V, Zuzarte M, Soo M, Heinemann SH, Daut J, Timothy KW, Keating MT, Sanguinetti M, Splawski I. Impaired interaction between the slide helix and the C-terminus of Kir2.1: A novel mechanism of Andersen Syndrome. Cardiovasc Res. 2007;75:748-757
Daccarett M, Pai RK, Abedin M, Segerson NM, Hamdan MH. A novel technique for right ventricular lead placement in a patinet with a persistent left superior vebna cava. Europace. 2007;9(3):200-2001
Colli Franzone P, Pavarino LF, Scacchi S, Taccardi B. Determining recovery times from transmembrane action potentials and unipolar electrograms in normal heart tissue. Functional Imaging and Modeling of the Heart. Vol 4466. New York. Springer Berlin Heidelberg;2007:139-149.
Colli Franzone P, Pavarino LF, Scacchi S, Taccardi B. Monophasic action potentials generated by bidomain modeling as a tool for detecting cardiac repolarization times. Am J Physiol Heart Circ Physiol. 2007;293:H1-H15
Cheng L, Kinard K, Rajamani R, Sanguinetti M. Molecular mapping of the binding site for a blocker of HCN2 pacemaker channels. J Pharmacol Exp Ther. 2007;322(3):931-939
Bridge JH, Savio-Galimberti E. Revealing the cellular basis of heart failure. Biophys J. 2007;93:1-2
Arnaout R, Ferrer T, Huisken J, Spitzer KW, Stainier DY, Tristani-Firouzi M. Zebrafish model for human long QT syndrome. Proc Natl Acad Sci U S A. 2007;104(27):11316-11321 online
Antzelevitch C, Pollevick GD, Cordeiro JM, Casis O, Sanguinetti M, Aizawa Y, Guerchicoff A, Pfeiffer R, Oliva A, Wollnik B, Gelber P, Bonaros EP, Jr., Burashnikov E, Wu Y, Sargent JD, Schickel S, Oberheiden R, Bhati. Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation. 2007;115(4):442-449
Akoum N, Hamdan MH. Atrial fibrillation and congestive heart failure: A two-way street. Curr Heart Fail Rep. 2007;4(2):78-83
Yilmaz B, MacLeod R. Generalized training subset selection for statistical estimation of epicardial activation maps from intravenous catheter measurements. Comput Biol Med. 2006:In press online
Wolters CH, Anwander A, Tricoche X, Weinstein DM, Koch MA, MacLeod R. Influence of tissue conductivity anisotropy on EEG/MEG field and return current computation in a realistic head model: a simulation and visualization study using high-resolution finite element modelin. Neuroimage. 2006;30(3):813-826 online
Weiss D, Seemann G, Sachse FB, Doessel O. Activity of self-depolarizing pacemaker cells bio-engineered in virtual heterogeneous ventricular tissue. Paper presented at:Computers in Cardiology, 2006
Vaughan-Jones RD, Villafuerte FC, Swietach P, Yamamoto T, Rossini A, Spitzer KW. pH-regulated Na(+) influx into the mammalian ventricular myocyte: the relative role of Na(+)-H(+) exchange and Na(+)-HCO co-transport. J Cardiovasc Electrophysiol. 2006;1(Suppl):S134-S140 online
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Sutherland DR, Adams J, Punske B. Methods for accurate measures of total ventricular activation time. Paper presented at:28th Annual Int'l Conference of IEEE Engineering in Medicine and Biology Society, 2006
Spitzer KW, Pollard AE, Yang L, Zaniboni M, Cordeiro JM, Huelsing DJ. Cell-to-cell electrical ineractions during early and late repolarization. J Cardiovasc Electrophysiol. 2006;1(Suppl):S8-S14 online
Seemann G, Hoper C, Sachse FB, Dossel O, Holden AV, Zhang H. Heterogeneous three-dimensional anatomical and electrophysiological model of human atrial. Phil Trans Roy Soc. 2006;364:1465-1481
Savio-Galimberti E, Ponce-Hornos JE. Effects of caffeine, verapamil, lithium, and KB-R7943 on mechanics and energetics of rat myocardial bigeminies. Am J Physiol Heart Circ Physiol. 2006;290(2):H613-623
Sanguinetti M, Tristani-Firouzi M. hERG potassium channels and cardiac arrhythmia. Nature. 2006;440(7083):463-469 online
Sachse FB, Cole M, Stinstra JG. A software framework for solving bioelectrical field problems based on finite elements. Paper presented at:IEEEE, 2006
Sachse FB. Modeling of cardiac contraction. Paper presented at:3rd International Symposium of Cell/Biodynamics Simulation Project, 2006
Punske B, . Cardiac resynchronization therapy: Finding the true meaning of synchrony. Heart Rhythm. 2006;3(3):311-312 online
Moreno AP, del Corsso C, Srinivas M, Urban-Maldonado M, Fort AG, Fishman GI, Spray DC. Transfection of mammalian cells with connexins and measurement of voltage sensitivity of their gap junctions.. Nat Protoc. 2006;1(4):1799-1809 online
McNary TG, Sohn K, Taccardi B, Sachse FB. Hemodynamics of hemorrhage simulated with an open-loop cardioppulmonary model, 2006
McNary TG, Sohn K, Taccardi B, Sachse FB. Mechano-electrical feedback mechanisms in cardiac tissue: Experimental setup and preliminary mesurement results. Paper presented at:2nd Annual Mountain West Biomedical Engineering , 2006
Lux RL, Gettes LS, Mason JW. Understanding proarrhythmic potential in therapeutic drug development: alternate strategies measuring and tracking repolarization. J Electrocardiol. 2006;39((4 Suppl)):S161-S164 online
Lian Q, Sohn K, Punske B. Propagation and electrical impedance changes due to ischemia. Hypoxia and referfusion in mouse hearts. Paper presented at:28th Annual Int'l Conference of IEEE Engineering in Medicine and Biology Society, 2006
Kerckhoffs R, Cole M, Sachse FB, Healy S, Neal M, Jones G, Basingthwaighte J, McCulloch A. From myocyte to torso: Spatially and temporally multi-scale simulation of cardic injury. Paper presented at:MMVR, 2006
Kamiya K, Niwa R, Mitcheson J, Sanguinetti M. Molecular determinants of hERG channel block. Mol Pharmacol. 2006;69(5):1709-1716 online
Kalifa J, Tanaka K, Zaitsev AV, Warren M, Vaidyanathan R, Auerbach D, Pandit S, Vikstrom KL, Ploutz-Snyder R, Talkachou A, Atienza F, Guiraudon G, Jalife J, Berenfeld O. Mechanisms of wave fractionation at boundaries of high-frequency excitation in the posterior left atrium of the isolated sheep heart during atrial fibrillation.. Circulation. 2006;113(5):626-633
Jones P, Cascio WE, Sachse FB. Design of an experimental setup for confocal imaging of cardiac microstructure. Paper presented at:2nd Annual Mountain West Biomedical Engineering , 2006
Hughes E, Taccardi B, Sachse FB. A heuristic streamline placement technique for visualization of electrical current flow. Paper presented at:J Flow Visualization and Image Processing, 2006
Geneser SE, Kirby M, Xiu D, Sachse FB. Stochastic markovian modeling of electrophysiology of ion channels: Reconstruction of standard deviations in macroscopic currents. J Theor Biol. 2006;245(4):627-637
Finlay DD, Nugent CD, Donnelly MP, Lux RL, McCullagh PJ, Black ND. Selection of optimal recording sites for limited lead body surface potential mapping: a sequential selection based approach.. BMC Med Inform Decis Mak. 2006;
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Ferrer T, Rupp J, Piper DR, Tristani-Firouzi M. The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel. J Biol Chem. 2006;281(18):12858-12864 online
Decher N, Kumar P, Gonzalez T, Pirard B, Sanguinetti M. Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation. Mol Pharmacol. 2006;70(4):1204-1211 online
Colli Franzone P, Pavarino LF, Taccardi B. Effects of transmural electrical heterogeneities and electrotonic interactions
on the dispersion of cardiac repolarization and action potential duration: A simulation study. Math Biosci. 2006;204(1):132-165 online
Chevalier P, Cottraux J, Mollard E, Sai N, Brun S, Burri H, Restier L, Adeleine P. Prevention of implantable defibrillator shocks by cognitive behavioral therapy: a pilot trial. Am Heart J. 2006;151(1):191
Casis O, Olesen SP, Sanguinetti M. Mechanism of action of NS1643, a novel hERG channel activator. Mol Pharmacol. 2006;69:658-665 online
Bridge JH, Savio-Galimberti E, Goldhaber JI, Davidson CJ, Sachse FB. Sparks evoked by cardiac action potentials are synchronized by the Na current and Na-Ca exchange: Studies on the function of couplons. Paper presented at:XXII Latin-American & 1st Ibero-American Congress of Physiological Science, 2006;Buenos Aires
Bridge JH, Davidson CJ, Savio-Galimberti E. A novel mechanism of pacemaker control that depends on high levels of cAMP and PKA-dependent phosphorylation: a precisely controlled biological clock. Circ Res. 2006;98(4):437-439
Bridge JH, Davidson CJ, Savio-Galimberti E. A novel mechanism of pacemaker control that depends on high levels of cAMP and PKA-dependent phosphorylation: A precisely controlled biological clock. Circ Res. 2006;98:437-439 online
