Sohn K, Sohn K, Wende AR, Abel ED, Moreno AP, Sachse FB, Punske BB. Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia.. Exp Physiol. 2013;98(3):746-57 online
Vivanco F, ( Franklin S, book chapter ). Heart proteomics : methods and protocols. volume 357. Totowa, N.J.. Humana Press. 2013.
Jou CJ, Barnett SM, Bian JT, Weng HC, Sheng X, Tristani-Firouzi M. An in vivo cardiac assay to determine the functional consequences of putative long QT syndrome mutations. Circ Res. 2013;112(5):826-30 online
Wülfers EM, Torres NS, Lenis G, Li H, Seemann G, Dössel O, Bridge JHB, Sachse FB. An automated approach to analyze microstructural remodeling from confocal microscopies of ventricular myocytes from diseased hearts. Biomed Tech (Berl). 2012;57(1):46-49 online
Veeraraghavan R, Salama ME, Poelzing S. Interstitial Volume Modulates the Conduction Velocity- Gap Junction Relationship. Am J Physiol Heart Circ Physiol. 2012;302(1):H278-286 online
Vaseghi M, Lux RL, Mahajan A, Shivkumar K. Sympathetic Stimulation Increases Dispersion of Repolarization in Humans with Myocardial Infarction. Am J Physiol Heart Circ Physiol.. 2012 online
Taylor TG, Venable PW, Shibayama J, Warren JW, Zaitsev AV. Role of KATP Channel in Electrical Depression and Asystole during Long-Duration Ventricular Fibrillation in Ex-Vivo Canine Heart . Am J Physiol Heart Circ Physiol. 2012 online
Sachse FB, Torres NS, Savio-Galimberti E, Aiba T, Kass DA, Tomaselli GF, Bridge JH. Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy. Circ Res. 2012;110(4):588-597 online
Rigby JR, Poelzing S. A novel frequency analysis method for assessing K(ir)2.1 and Na (v)1.5 currents.. Ann Biomed Eng. 2012;40(4):946-954 online
McNary TG, Spitzer KW, Holloway H, Bridge JHB, Kohl P, Sachse FB. Mechanical modulation of the transverse tubular system of ventricular cardiomyocytes. Prog Biophys Mol Biol. 2012;110:218-225 online
Lasher RA, Pahnke AQ, Johnson JM, Sachse FB, Hitchcock RW. Electrical stimulation directs engineered cardiac tissue to an age-matched native phenotype. J Tissue Eng. 2012;3(1) online
Larsen AP, Sciuto KJ, Moreno AP, Poelzing S. The voltage-sensitive dye di-4-ANEPPS slows conduction velocity in isolated guinea pig hearts. Heart Rhythm. 2012 online
Kekenes-Huskey PM, Cheng Y, Hake JE, Sachse FB, Bridge JH, Holst MJ, McCammon JA, McCulloch AD, Michailova AP. Modeling effects of l-type Ca2+ current and Na+-Ca2+ exchanger on Ca2+ trigger flux in rabbit myocytes with realistic t-tubule geometries. Front Physiol. 2012 online
Garg V, Sachse FB, Sanguinetti M. Tuning of EAG K+ channel inactivation: molecular determinants of amplification by mutations and a small molecule. J Gen Physiol. 2012;140(3):307-324 online
Franklin S, Vondriska TM. Genomes, proteomes, and the central dogma. Circulation Cardiovasc Genet.. 2012;4(5):576 online
Franklin S, Chen H, Mitchell-Jordan SA, Ren S, Wang Y, Vondriska TM. Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. Mol Cell Proteomics. 2012 online
Frank DU, Carter KL, Thomas KR, Burr RM, Bakker ML, W.A. C, Tristani-Firouzi M, Bamshad MJ, Christoffels VM, Moon AM. Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis . Proc Natl Acad Sci U S A. 2012;109(3):E154-163 online
Christophersen IE, Olesen MS, Liang B, Andersen MN, Larsen AP, Nielsen JB, Haunsø S, Olesen SP, Tveit A, Svendsen JH, Schmitt N. Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation.. Eur Heart J.. 2012 online
Blaufox AD, Tristani-Firouzi M, Seslar S, Sanatani S, Trivedi B, Fischbach P, Paul T, Young ML, Tisma-Dupanovic S, Silva J, Cuneo B, Fournier A, Singh H, Tanel RE, Etheridge SP. Congenital Long QT 3 in the Pediatric Population. Am J Cardiol. 2012;109(10):1459-1465 online
Monte E, Chen H, Kolmakova M, Parvatiyar M, Vondriska TM, Franklin S. Quantitative analysis of chromatin proteomes in disease. J Vis Exp. 2012(70) online
Mitchell-Jordan S, Chen H, Franklin S, Stefani E, Bentolila LA, Vondriska TM. Features of endogenous cardiomyocyte chromatin revealed by super-resolution STED microscopy. J Mol Cell Cardiol. 2012;53(4):552-8 online
Chen H, Monte E, Parvatiyar MS, Rosa-Garrido M, Franklin S, Vondriska TM. Structural considerations for chromatin state models with transcription as a functional readout. FEBS Lett. 2012;586(20):3548-54 online
Sohn K, Sachse FB, Moreno AP, Ershler PR, Wende AR, Abel ED, Punske BB. The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts.. IEEE Trans Biomed Eng. 2011;58(11):3175-3183 online
Sheets MF, Chen T, Hanck DA. Lidocaine Partially Depolarizes the S4 Segment in Domain IV of the Sodium Channel. European Journal of Physiology. 2011;461:91-97 online
Saegusa N, Moorhouse E, Vaughan-Jones RD, Spitzer KW. Influence of pH on Ca2+ current and its control of electrical and Ca2+ signaling in ventricular myocytes. J Gen Physio. 2011;138(5):537-559 online
Romero D, Sachse FB, Sebastian R, Frangi A. Towards high resolution computational models of the cardiac conduction system: a pipeline for characterization of Purkinje-ventricular-junctions. volume 6666. Springer. 2011.
Rigby JR, Poelzing S. Recapitulation of an ion channel IV curve using frequency components. J Vis Exp. 2011(48) online
Radwanski PB, Poelzing S. NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome. Cardiovasc Res. 2011 online
Quinn TA, Granite S, Allessie MA, Antzelevitch C, Sachse FB, et al. Minimum information about a cardiac electrophysiology experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol. 2011 online
Niederer SA, Kerfoot E, Benson AP, Bernabeu MO, Bernus O, Bradley C, Cherry EM, Clayton R, Fenton FH, Garny A, Heidenreich E, Land S, Maleckar M, Pathmanathan P, Plank G, Rodríguez JF, Roy I, Sachse FB, Seemann G. Verification of cardiac tissue electrophysiology simulators using an N-version benchmark. Philos Transact A Math Phys Eng Sci. 2011;369(1954):4331-4351 online
Navarro-Polanco RA, Moreno Galindo EG, Ferrer-Villada T, Arias M, Rigby JR, Sanchez-Chapula JA, Tristani-Firouzi M. Conformational changes in the M2 muscarinic receptor induced by membrane voltage and agonist binding. J Physiol. 2011 online
Moreno-Galindo EG, Sanchez-Chapula JA, Sachse FB, Rodriguez-Paredes JA, Tristani-Firouzi M, Navarro-Polanco RA. Relaxation gating of the acetylcholine-activated inward rectifier K+ current (IKACh) is mediated by intrinsic voltage-sensitivity of the muscarinic receptor. J Physiol. 2011;589(Pt 7):1755-1767 online
McNary TG, Bridge JH, Sachse FB. Strain transfer in ventricular cardiomyocytes to their transverse tubular system revealed by scanning confocal microscopy. Biophys J. 2011;100(10):L53-55 online
Lux RL, Gettes LS. Repolarization heterogeneity and rate dependency in a canine rapid pacing model of heart failure. J Electrocardiol. 2011;44(6):730-735 online
Lux RL. Body Surface Potential Mapping In Comprehensive Electrocardiology. Comprehensive Electrocardiology. Springer Verlag;2011:1361-1374.
Limberg SH, Netter MF, Rolfes C, Rinné S, Schlichthörl G, Zuzarte M, Vassiliou T, Moosdorf R, Wulf H, Daut J, Sachse FB, Decher N. TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes.. Cell Physiol Biochem. 2011;28(4):613-624 online
Li Y, Franklin S, Zhang M, Vondriska TM. Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton’s tyrosine kinase. Protein Science. 2011;20(1):140-149 online
Larsen AP, Steffensen AB, Grunnet M, Olesen SP. Extracellular Potassium Inhibits Kv7.1 Potassium Channels by Stabilizing an Inactivated State. Biophys J.. 2011;101(4):818-827 online
Lackey DP, Carruth ED, Lasher RA, Boenisch J, Sachse FB, R.W. H. Three-dimensional modeling and quantitative analysis of gap junction distributions in cardiac tissue.. Ann Biomed Eng. 2011;39(11):2683-2694 online
Javaherian AD, Yusifov T, Pantazis A, Franklin S, Gandhi CS, Olcese R. Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus. J. Biol. Chem. 2011;286(23):20701-20709 online
Grunnet M, Abbruzzese J, Sachse FB, Sanguinetti MC. Molecular determinants of human ether-a-go-go-related gene 1 (hERG1) K+ channel activation by NS1643. Mol Pharmacol. 2011;79(1):1-9 online
Gonzalez AG, Zavala LC, Moreno AP, San Juan ER, Ferrara JG, Espinosa LR, Marcelin Jimenez G. Pharmacokinetics of diphenylboroxazolidones of L-alpha-amino acids with activity on the CNS: quantification in rat DBS by UPLC-MS/MS. Bioanalysis. 2011;3(4):439-448 online
Garg V, Stary-Weinzinger A, Sachse FB, Sanguinetti MC. Molecular Determinants for Activation of Human Ether-à-go-go-related Gene 1 Potassium Channels by 3-Nitro-N-(4-phenoxyphenyl) Benzamide. Mol Pharmacol. 2011;80(4):630-637 online
Fozzard HA, Sheets MF, Hanck DA. The Sodium Channel as a Target for Local Anesthetic Drugs. Front Pharmacology. 2011;2:1-6 online
Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M. Molecular Coupling in the Human ether-a-go-go-related gene-1 (hERG1) K+ Channel Inactivation Pathway. J Biol Chem. 2011;286(45):39091-39099 online
Decher N, Wemhöner K, Rinné S, Netter MF, Zuzarte M, Aller MI, Kaufmann SG, Li XT, Meuth SG, Daut J, Sachse FB, Maier SK. Knock-Out of the Potassium Channel TASK-1 Leads to a Prolonged QT Interval and a Disturbed QRS Complex. Cell Physiol Biochem. 2011;28(1):77-86 online
Clayton RH, Bernus O, Cherry EM, Dierckx H, Fenton FH, Mirabella L, Panfilov AV, Sachse FB, Seemann G, Zhang H. Models of cardiac tissue electrophysiology: progress, challenges and open questions. Prog Biophys Mol Biol. 2011;104(1-3):22-48 online
Ajiro T, Saegusa N, Giles WR, Stafforini DM, Spitzer KW. Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocyes. Am J Physiol Heart & Circ Physiol. 2011;In press online
Zhang MJ, Franklin S, Li Y, Wang S, Ru X, Mitchell-Jordan S, Mano H, Stefani E, Ping P, Vondriska TM. Stress signaling by Tec tyrosine kinase in ischemic myocardium.. Am J Physiol Heart Circ Physiol. 2010;299(3):713-722 online
Zahradnikova A, Gaburjakova M, Bridge JH, Zahradnik I. Challenging quantal calcium signaling in cardiac myocytes. J Gen Physiol. 2010;136(5):581-583 online
Warren M, Spitzer KW, Steadman BW, Rees TD, Venable P, Taylor T, Shibayama J, Yan P, Wuskell JP, Loew LM, Zaitsev AV. High precision recording of the action potential in isolated cardiomyocytes using the near-infrared fluorescent dye di-4-ANBDQBS. Am J Physiol Heart Circ Physiol. 2010;299(4):H271-H1281 online
Venable PW, Taylor TG, Shibayama J, Warren M, Zaitsev AV. Complex structure of electrophysiological gradients emerging during long-duration ventricular fibrillation in the canine heart. Am J Physiol Heart Circ Physiol. 2010;299(5):H1405-1418 online
Torres NS, Larbig R, Rock A, Goldhaber JI, Bridge JH. Na+ currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+ channels. J Physiol. 2010;588(Pt 21):4249-4260 online
Swietach P, Spitzer KW, Vaughan-Jones RD. Modeling calcium waves in cardiac myocytes importance of calcium diffusion. Front Biosci. 2010;15:661-680 online
Strom M, Wan X, Poelzing S, Ficker E, Rosenbaum DS. Gap junction heterogeneity as mechanism for electrophysiologically distinct properties across the ventricular wall. Am J Physiol Heart Circ Physiol. 2010;298(3):H787-794 online
Sheets MF, Fozzard HA, Lipkind GM, Hanck DA. Sodium Channel Molecular Conformations and Antiarrhythmic Drug Affinity. Trends. Cardiovasc. Med.. 2010;20:16-21 online
Seemann G, Sachse F, Karl J, Weiss D, Heuveline V, Doessel O. Framework for modular, flexible and efficient solving the cardiac biodomain equation using PETSc. Paper presented at:Prog Industrial Math ECMI 2008, Mathematics in Industry, 2010
Sachse F. Patient-specific modeling of structure and function of cardiac cells. Patient-Specific Modeling of the Cardiovascular System. 1 edl. Berlilln, Heidelberg, New York. Springer;2010.
Radwanski PB, Veeraraghavan R, Poelzing S. Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome. Heart Rhythm. 2010;7(10):1428-1435 e1421 online
Paulsson AK, Franklin S, Mitchell-Jordan SA, Ren S, Wang Y, Vondriska TM. Post-translational regulation of calsarcin-1 during pressure overload induced cardiac hypertrophy. . J Mol Cell Cardiol. 2010;48(6):1206-1214 online
Neco P, Rose B, Huynh N, Zhang R, Bridge JH, Philipson KD, Goldhaber JI. Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart. Biophys J. 2010;99(3):755-764 online
Moreno-Galindo EG, Barrio-Echavarria GF, Vasquez JC, Decher N, Sachse FB, Tristani-Firouzi M, Sanchez-Chapula JA, Navarro-Polanco RA. Molecular basis for a high-potency open-channel block of Kv1.5 channel by the endocannabinoid anandamide. Mol Pharmacol. 2010;77(5):751-758 online
Mason NO, Bishop CJ, Kfoury AG, Lux RL, Crawford C, Horne BD, Stoker S, Clayson SE, Rasmusson BY, Reid BB. Noninvasive predictor of HeartMate XVE pump failure by neural network and waveform analysis. ASAIO J. 2010;56(1):1-5 online
Larsen AP, Olesen SP, Grunnet M, Poelzing S. Pharmacological activation of IKr impairs conduction in guinea pig hearts. J Cardiovasc Electrophysiol. 2010;21(8):923-929 online
Larsen AP, . Role of ERG1 isoforms in modulation of ERG1 channel trafficking and function. Pflugers Arch. 2010;460(5):803-812 online
Larbig R, Torres N, Bridge JH, Goldhaber JI, Philipson KD. Activation of reverse Na+-Ca2+ exchange by the Na+ current augments the cardiac Ca2+ transient: evidence from NCX knockout mice. J Physiol. 2010;588(Pt 17):3267-3276 online
Kozoriz MG, Bechberger JF, Bechberger GR, Suen MW, Moreno AP, Maass K, Willecke K, Naus CC. The connexin43 C-terminal region mediates neuroprotection during stroke. J Neuropathol Exp Neurol. 2010;69(2):196-206 online
Jou CJ, Spitzer KW, Tristani-Firouzi M. Blebbistatin effectively uncouples the excitation-contraction process in zebrafish embryonic heart. Cell Physiol Biochem. 2010;25(4-5):419-424 online
French RJ, Yoshikami D, Sheets MF, Olivera BM. The Tetrodotoxin Receptor of Voltage-Gated Sodium Channels—Perspectives from Interactions with µ-Conotoxins. Mar. Drugs. 2010;8:2153-2161 online
Franklin S, Zhang M, Chen H, Paulsson AK, Mitchell-Jordan SA, Li Y, Ping P, Vondriska TM. Specialized compartments of cardiac nuclei exhibit distinct proteome anatomy. Mol Cell Proteomics. 2010;10(1)
Finlay DD, Nugent CD, Donnelly MP, Lux RL. Eigenleads: ECG leads for maximizing information capture and improving SNR. IEEE Trans Inf Technol Biomed. 2010;14(1):69-78 online
Barry WH, Zhang XQ, Halkos ME, Vinten-Johansen J, Saegusa N, Spitzer KW, Matsuoka N, Sheets M, Rao NV, Kennedy T. Non-Anticoagulant Heparin Reduces Myocyte Na+ and Ca2+ Loading During Simulated Ischemia and Decreases Reperfusion Injury. Am. J. Physiol.. 2010;298:H102-H111 online
Akoum NW, Wasmund SL, Lux RL, Hamdan MH. Reverse Electrical Remodeling of the Ventricles Following Successful Restoration of Sinus Rhythm in Patients with Persistent Atrial Fibrillation. Pacing Clin Electrophysiol. 2010;33(10):1198-1202 online
Abbruzzese J, Sachse F, Tristani-Firouzi M, Sanguinetti M. Modification of hERG1 channel gating by Cd2+. J Gen Physiol. 2010;136(2):203-224 online
