Mathematical modeling and computational simulation complement the electrophysiological and confocal imaging studies at CVRTI. Areas of modeling and simulation range from molecular to cellular to whole heart level.
Structural models of ion channels are applied in molecular dynamics simulations to gain insights in protein function and drug action. Electrophysiology of ion channels, cardiac cells and tissue is modeled with various mathematical approaches such as Markov models, diffusion-excitation equations and cellular automata.
These models quantitatively describe measurement data and are integrated with descriptions of anatomy, mechanics and metabolism. Major applications of the models are in understanding of mechanisms of cardiac diseases, evaluation of methods for their diagnosis and treatment.