Bioengineering 6460 Electrophysiology and Bioelectricity of Tissues
Fall Semester, 2007
Syllabus

Rob MacLeod, Steve Poelzing, Bonnie Punske, Frank Sachse,

and Jeroen Stinstra

• Description
• Class time and venue
• Instructors
• Text and resource materials
• Grading
• Lectures and Reading Material
• Instructor absences
• About this document ...

Description

The goal of this class is to provide an intermediate level overview of electrophysiology and bioelectricity at the tissue level to graduate students with special interest in cardiology and neurosciences. We will develop the central electrical mechanisms from sets of coupled cells to the intact organ, building on those that are common to many electrically active cells in the body. The approach will be a combination of qualitative explanations, quantitative analysis, and mathematical simulation. The class format will include didactic lectures, group discussion of primary literature, quantitative problem solving exercises, writing assignments, and laboratory experiences. The prerequisite for the course are Bioengineering 6000 or equivalent or permission of the instructor and knowledge of university undergraduate level calculus and physics. Homework assignments will require the use of Matlab and the use of web based transfer of computer files.

Class time and venue

Class times: Wednesday and Friday, 3:15-4:30 pm
Classroom: CVRTI Library/Meeting room
Credits: three credit-hours

Instructors

Name	Phone	Email	Office	Hours
Rob MacLeod (RM)	7-9511	macleod@cvrti.utah.edu	CVRTI/MEB	by appt.
Steve Poelzing (SP)	5-1862	poelzing@cvrti.utah.edu	CVRTI	by appt.
Bonnie Punske (BP)	7-9507	punske@cvrti.utah.edu	CVRTI	by appt.
Jeroen Stinstra (JS)	7-9508	jeroen@cvrti.utah.edu	CVRTI	by appt.

(See also www.cvrti.utah.edu/personnel.html for more information)

Text and resource materials

• Bioelectricity: A Quantitative Approach, Second Edition by Robert Plonsey and Roger C. Barr, Kluwer Academic/Plenumm Press

  There should be copies of the book at the bookstore but I encourage you to use the web to search down copies. Either the first or the second edition will work for the course. The third edition has also just appeared and we will make use of material from this text only with suitable notes and materials.

• Bioelectricity and Biomagnetism by Ramesh M. Gulrajani. This book is the best available but sold at an insane price so we cannot in good conscience ask you to purchase it. If you find a cheap copy somewhere, grab it!

• Bioelectromagnetism by Jaakko Malmivuo and Robert Plonsey is good too and very cheap-free in fact on the web site http://butler.cc.tut.fi/~malmivuo/bem/bembook

• Articles and selected readings from the literature.

Grading

The grade for the course will be based on homework assignments, writing assignments, and laboratory exercises.

Lectures and Reading Material

Date	Instructor	Topic* mathend000#	Reading $\dagger$ mathend000#
Week #1, Aug. 20-24	SP	Introduction and Review of Cellular Electrophysiology	3
Week #2, Aug 27-31	SP	Cell to cell communication
September 3	Labor Day Holiday
Week #3, Sept. 4-7	JS	Mathematical and computational background	1,2
Week #4, Sept. 10-14	RM	Mathematical and computational background	1,2
Week #5, Sept. 17-21	RM	Spread of activation	10
Week #6, Sept. 24-28	RM	Simulation of spread of activation	10
Week #7, Oct. 1-5	BP	Measurement of bioelectric fields
Oct 8-12	Fall Break
Week #8, Oct. 15-19	JS	Simulation of spread of activation	10
Week #9, Oct. 22-26	RM	Bioelectric sources 1
Week #10, Oct 29-Nov 2	RM	Bioelectric sources 2
Week #11, Nov. 5-9	RM	Electrocardiography & electroencephalography	9
Week #12, Nov. 12-16	JS	Biomagnetism
Week #13, Nov. 19-21	JS	Biomagnetism
Nov 22-23	Thanksgiving
Week #14, Nov 26-30	RM	Bioelectric Forward and Inverse problems
Week #15, Dec 3-7	RM	Bioelectric Forward and Inverse problems

^$\dagger$ mathend000# Chapter numbers from Plonsey and Barr

Instructor absences

Rob MacLeod

• August 20-September 8
• October 1-4
• October 5-10
• November 3-5
• November 15-17

Steve Poelzing

• TBA

Bonnie Punske

• October 29-30
• November 4-7

Jeroen Stinstra

• September 10-14
• October 1-4
• November 17-December 7

About this document ...

Bioengineering 6460 Electrophysiology and Bioelectricity of Tissues
Fall Semester, 2007
Syllabus

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